FOB / Transferrin (TRF)
Combo Rapid Test
Rapid chromatographic immunoassay for the simultaneous qualitative detection of human Hemoglobin (FOB) and Transferrin (TRF) in fecal specimens. Comprehensive diagnostic screening for both upper and lower gastrointestinal hemorrhage. Results in 5 to 10 minutes.
Overcoming Hemoglobin Degradation in Upper GI Bleeding
Standard fecal occult blood (FOB) tests rely strictly on hemoglobin, which is rapidly denatured by gastric acid and digested by pancreatic proteases during transit through the upper digestive tract. Transferrin is enzymatically resilient throughout gastrointestinal transit, providing unmatched sensitivity for both upper and lower gastrointestinal lesions.
Human Hemoglobin (FOB)
Specific immunochemical capture of intact human hemoglobin from the colon and rectum, the gold-standard biomarker for colorectal cancer screening.
- Detects bleeding polyps and adenocarcinomas
- No dietary restrictions (unlike guaiac)
- Calibrated 50 ng/mL cut-off sensitivity
Human Transferrin (TRF)
Transferrin resists proteolytic degradation by pepsin and trypsin, maintaining diagnostic integrity even after extensive gastric transit.
- Detects gastric ulcers and stomach cancers
- Identifies bleeding esophageal varices
- High analytical sensitivity (10 ng/mL)
Comprehensive GI Hemorrhage Triage
Eliminates false-negative blind spots by providing complete anatomical coverage of gastrointestinal tract bleeding in a single 5–10 minute cassette.
- Simultaneous dual-line visual differentiation
- Ideal for executive checkups and outpatient clinics
- Rapid B2B clinic fulfillment across the UAE
Clinical Agreement vs. Colonoscopy & Endoscopy Benchmarks
Multi-Center Clinical Evaluation (n=820)| Diagnostic Parameter | Hemoglobin (FOB) Channel | Transferrin (TRF) Channel | Combined Assay Performance |
|---|---|---|---|
| Diagnostic Sensitivity | 95.2% (95% CI: 91.8% – 97.5%) | 96.0% (95% CI: 92.5% – 98.1%) | 96.8% (Overall GI Bleeds) |
| Diagnostic Specificity | 99.1% (95% CI: 97.8% – 99.7%) | 98.9% (95% CI: 97.4% – 99.6%) | 98.8% |
| Total Accuracy | 98.4% | 98.2% | 98.8% |
| Analytical Cut-Off | 50 ng/mL human hemoglobin | 10 ng/mL human transferrin | Zero Cross-Reactivity with Animal Blood |
4-Step Non-Invasive Stool Sampling Protocol
Hygienic sampling collection tubes protect laboratory personnel while ensuring standardized antigen extraction.
Fecal Sampling
Unscrew the green cap of the collection tube. Insert the spiral sampling stick into 3 distinct sites of the stool specimen to harvest approximately 50 mg of feces.
Extraction Agitation
Insert the applicator back into the collection tube and tighten the cap securely. Shake vigorously for 15 seconds to completely suspend and extract antigens in the buffer.
Cassette Inoculation
Snap off the dispensing dropper tip of the tube cap. Invert the tube and dispense exactly 2 drops (approx. 80 µL) into the cassette sample well (S).
Chromatographic Readout
Observe the emergence of colored bands between 5 and 10 minutes. Do not interpret or document diagnostic results after 15 minutes.
Diagnostic Interpretation Matrix
Differentiates upper GI, lower GI, and pan-gastrointestinal bleeding patterns at a glance.
Positive Differential Findings
Presence of Control line (C) accompanied by FOB and/or TRF test lines.
Negative & Invalid Results
Internal quality control and procedural guidelines.
Everything Included in the Kit Box
Supplied with pre-filled hygienic buffer collection tubes for safe and clean patient stool collection.
Frequently Asked Questions
Need validation dossiers, regulatory certificates, or bulk clinic pricing? Contact our gastroenterology diagnostic specialists in Dubai.
Contact Clinical SpecialistWhy is Transferrin tested alongside Hemoglobin?
Hemoglobin degrades in the upper gastrointestinal tract due to proteolytic enzymes. Transferrin is stable against proteolysis, allowing detection of upper GI bleeds that standard FOB tests miss.
Are dietary restrictions required before testing?
No. The immunochemical method is specific to human hemoglobin and human transferrin, eliminating false positives from dietary red meat, iron supplements, or vegetables.
What are the cut-off concentrations?
50 ng/mL for human hemoglobin and 10 ng/mL for human transferrin in extraction buffer.
What is included in the kit?
25 test cassettes, 25 collection tubes with buffer, desiccant, and package insert.
How to order for gastroenterology clinics in Dubai?
QuRapid provides rapid delivery across the UAE with complete CE-IVD batch documentation and temperature-controlled handling.
Equip Your Clinic With QuRapid FOB / TRF Combo Rapid Tests
Order CE-IVD certified FOB / Transferrin Combo Rapid Test Kits with same-day dispatch across Dubai, Abu Dhabi, and the UAE. Wholesale volume pricing available for gastroenterology departments, wellness centers, and hospital laboratories.